Publications

The Unit’s researchers are recognized worldwide and frequently invited to present their work at national and international conferences and congresses and discuss new treatments and therapeutic approaches related to this disease. Several prestigious international excellence awards have been awarded to the Unit’s researchers for the quality and originality of their contributions to osteoarthritis.

Below is a short list of some of their recent and relevant works.

Scientific articles

  1. Otis, C., Cristofanilli, K.A., Frezier, M., Delsart, A., Martel-Pelletier, J., Pelletier, J.P., Beaudry, F., Lussier, B., Boyer, A., Troncy, E.: Predictive and concurrent validity of pain sensitivity phenotype, neuropeptidomics and neuroepigenetics in the MI-RAT osteoarthritic surgical model in rats. Cell Dev. Biol. 12:14000650. doi.org/10.3389/fcell.2024.1400650.
  2. Pelletier, J.P., Paiement, P., Martel-Pelletier, J.: Sur le chemin de la conquête d’un pronostic précoce de la gonarthrose progressive: avancées prometteuses. Acad. Natl. Med. 208(5) :679-690, 2024 doi.org/10.1016/j.banm.2024.03.002.
  3. Delsart, A., Otis, C., Leung, V.S.Y., Labelle, E., Moreau, M., Frezier, M., Drag, M., Martel-Pelletier, J., Pelletier, J.P., Troncy, E.: Concurrent validation of MI-CAT(V), a clinical metrology instrument for veterinarians assessing osteoarthritis pain in cats, through testing for firocoxib analgesic efficacy in a prospective, randomized, controlled and blinded study. Animals 14(5):711, 2024. org/10.3390/ani14050711.
  4. Pelletier, J.P., Paiement, P., Dorais, M., Raynauld, J.P., Martel-Pelletier, J.: Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: Role of nonsurgical injury. Adv. Chronic Dis. 14:1-18, 2023. doi.org./10.1177/20406223231169715.
  5. Martel-Pelletier, J., Paiement, P., Pelletier, J.P.: Magnetic resonance imaging assessments for knee segmentation and their use in combination with machine/deep learning as predictors of early osteoarthritis diagnosis and prognosis. Adv. Musculoskelet. Dis. 15:1-39, 2023. doi.org/10.1177/1759720X231165560.
  6. Bonakdari, H., Pelletier, J.P., Abram, F., Martel-Pelletier, J.: A machine learning model to predict knee osteoarthritis cartilage volume changes over time using baseline bone curvature. Biomedicines10:1247, 2022 doi.org/10.3390/biomedicines10061247.
  7. Bonakdari, H., Pelletier, J.P., Blanco, F.J., Rego-Pérez, I., Durán-Sotuela, A., Jamshidi, A., Abram, F., Martel-Pelletier, J.: Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers. BMC Medicine 20:316, 2022 doi.org/10.1186/s12916-022-02491-1.
  8. Martel-Pelletier, J., Tardif, G., Paiement, P., Pelletier, J.P.: Common biochemical and magnetic resonance imaging biomarkers of early knee osteoarthritis and of exercise/training in athletes. A narrative review. Diagnostics (Special Issue: Biomarkers in OA) 11:1488, 2021. https://doi.org/10.3390.diagnostics1081488.
  9. Jamshidi, A., Pelletier, J.P., Labbe, A., Abram, F., Martel-Pelletier, J.*, Droit, A.*: Machine learning-based individualized survival prediction model for total knee replacement in osteoarthritis: Data from the Osteoarthritis Initiative.Arthritis Care & Res. 73(10):1518-1527, 2021. doi.org/10.1002/acr.24601. *Indicates that both senior researchers contributed equally to the completion of this work
  10. Bonakdari, H., Jamshidi, A., Pelletier, J.P., Abram, F., Tardif, G., Martel-Pelletier, J.: A warning machine learning tool for early knee osteoarthritis structural progressor patient screening: Making headway on precision medicine.  Adv. Musculoskel. Dis. 13:1-16, 2021. doi :10.1177/1759720X21993254.
  11. Pelletier, J.P., Raynauld, J.P., Abram, F., Dorais, M., Paiement, P., Martel-Pelletier, J.: Intra-articular corticosteroid knee injection induces a reduction in meniscal thickness with no treatment effect on cartilage volume: A case-control study. Rep. 10(1):13789, 2020. doi.org/10.1038/s41598-020-70064-4.
  12. Jamshidi, A., Leclercq, M., Labbe, A., Pelletier, J.P., Abram, F., Droit, A., Martel-Pelletier, J.: Identification of the most important features of knee osteoarthritis structural progressors using machine learning methods. Adv. Musculoskelet. Dis. 12:1-12, 2020. doi: 10.1177/1759720X20933468.
  13. Fleischmann, R.M., Bliddal, H., Blanco, F.J., Schnitzer, T.J., Peterfy, C., Chen, S., Wang, L., Feng, S., Conaghan, P.G., Berenbaum, F., Pelletier, J.P., Martel-Pelletier, J., Vaeterlein, O., Kaeley, G.S., Liu, W., Kosloski, M.P., Levy, G., Zhang, L., Medema, J.K., Levesque, M.C.: A phase II trial of lutikizumab, an anti-interleukin 1α/β dual variable domain immunoglobulin, in knee osteoarthritis patients with synovitis.Arthritis Rheumatol. 71(7):1056-1069, 2019.
  14. Dorais, M., Martel-Pelletier, J., Raynauld, J.P., Delorme, P., Pelletier, J.P.: Impact of oral osteoarthritis therapeutics usage among other risk factors on total knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort. Arthritis Res. & Ther. 20(1):172, 2018.
  15. Pelletier, J.P., Raynauld, J.P., Abram, F., Dorais, M., Delorme, P., Martel-Pelletier, J.: Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative. Arthritis Res. Ther.20(1):40, 2018.